Scientific Studies

We are pleased to share the following scientific studies authored by the first users of REVEAL FGS.


Qualitative Head-to-Head Comparison of Headlamp and Microscope during Resection of Glioblastoma
Fraser Henderson Jr MD, Evgenii Belykh MD, Aleander Ramos MD, Theodore H. Schwartz MD

Head-to-Head Comparison


Development and validation of a triple-LED surgical loupe device for fluorescence-guided resections with 5-ALA

Suero Molina, E., Hellwig, S. J., Walke, A., Jeibmann, A., Stepp, H., & Stummer, W. (2021). Development and validation of a triple-LED surgical loupe device for fluorescence-guided resections with 5-ALA, Journal of Neurosurgery (published online ahead of print 2021). While used with permission, no endorsement of any pharmaceutical, device, therapy or technique by publisher should be inferred. Full text is available at

Figure 1

FIG. 1 Established BLUE400 (Kinevo) and triple-LED light source normalized fluorescence excitation and background illumination spectra in comparison to the PPIX excitation spectrum, measured from a glioblastoma tissue specimen (black curve). The right-hand graph depicts a detail of the left-hand graph with an enlarged scale to better illustrate the emission of the background illumination at approximately 450 nm. Blue curve (Kinevo excitation): spectrum of Kinevo blue mode illumination measured at the site of the tissue; light brown curve: spectrum measured at the ocular from a white surface after having passed the long-pass 440-nm observation filter. Purple curves depict the emission spectra of the two LED beams, with the 450-nm beam driven with 2 mA (low setting) or 5 mA (high setting), respectively. Note overlap of both curves at the 409-nm LED emission band. PpIX-exc = PPIX excitation.

CLICK HERE to read the full article titled Development and validation of a triple-LED surgical loupe device for fluorescence-guided resections with 5-ALA


Guided by the Light:
Using 5-ALA to Resect Head and Neck Tumors

Featuring Alfred M.C. Iloreta, Jr., MD, Assistant Professor Otolaryngology-Head and Neck Surgery and Neurosurgery

Guided by the Light: Using 5-ALA


Additional Scientific Papers

Histology of high-grade glioma samples resected using 5-ALA fluorescent
headlight and loupe combination

Alexandra M. Giantini-Larsen, Natasha Kharas, David Pisapia, Theodore H. Schwartz

Histology Paper

Purpose 5-Aminolevulinic acid (5-ALA) fluorescence-guided resection of high-grade gliomas (HGG) increases the extent of resection (EOR) and progression-free survival. The headlamp/loupe combination has been introduced a method of performing fluorescent-guided surgery. This study aims to understand the correlation between fluorescent intensity and histology and between residual fluorescence and radiographic EOR utilizing the headlamp/loupe device.

CLICK HERE to link to full article

5-Aminolevulinic Acid Enabled Surgical Loupe System Study

A Novel 5-Aminolevulinic Acid-Enabled Surgical Loupe System—A Consecutive Brain Tumor Series of 11 Cases
Zhang, Xiaoran MD, MS*; Jaman, Emade BS‡; Habib, Ahmed MD§; Ozpinar, Alp MD*; Andrews, Edward MD*; Amankulor, Nduka M. MD*,§; Zinn, Pascal O. MD, PhD*,§
CLICK HERE to read abstract or link to full article


The Evolution of 5-Aminolevulinic Acid Fluorescence Visualization:
Time for a Headlamp/Loupe Combination

Alexandra M Giantini-Larsen 1 , Whitney E Parker 1 , Steve S Cho 2 , Jacob L Goldberg 1 , Joseph A Carnevale 1 , Alex P Michael 3 , Clare W Teng 2 , Emma De Ravin 2 , Cameron W Brennan 4 , John Y K Lee 2 , Theodore H Schwartz 5
CLICK HERE to read the abstract or link to full article